THE COMPLICATED CLINICAL COURSE IN A CASE OF ATYPICAL LIPODYSTROPHY AFTER DEVELOPMENT OF NEUTRALIZING ANTIBODY TO METRELEPTIN: TREATMENT WITH SETMELANOTIDE

A patient with atypical partial lipodystrophy who had a transient initial response to metreleptin experienced acute worsening of her metabolic state when neutralizing antibodies against metreleptin appeared.Because her metabolic status continued to deteriorate, a therapeutic trial with melanocortin-4 receptor agonist setmelanotide, that is believed

We consider the problem of autonomous landmine detection using a team of mobile robots.Previous research on robotic landmine detection mostly employs a single robot equipped with a landmine Dryer Vent detection sensor to detect landmines.We envisage that the quality of landmine detection can be significantly improved if multiple robots are coordina

The Polycomb repressive complex 1 (PRC1) is required for decisions of stem cell fate.In mouse embryonic stem cells (ESCs), two major variations of PRC1 complex, defined by the mutually exclusive presence of Cbx7 or RYBP, have been identified.Here, we show that although the genomic localization of the Cbx7- and RYBP-containing PRC1 complexes overlap